RNA Details
Disease Name
glaucoma
Tissue
eye
RNA Symbol
mir-139
RNA ID
RNA Type
miRNA
Alteration Pattern
dysregulation
Species
homo sapiens
Detection Methods
RT-PCR; immunofluorescence; dual-lucimmunofluorescenceerase reporter assay etc.
Target
NA
Pathway
WNT SIGNALING PATHWAY; CATENIN BETA 1
PubMed ID
Title
The Smad2/3/4 complex binds miR-139 promoter to modulate TGFbeta-induced proliferation and activation of human Tenon's capsule fibroblasts through the Wnt pathway
Year
2019
Function
"We demonstrated a new mechanism of htf activation and proliferation from the perspective of mirna regulation, which may provide new strategies for improving the fibrosis after the glaucoma filtration surgery."